All issues > Volume 33(8); 1990

Original Article

J Korean Pediatr Soc. 1990;33(8):1057-1064. Published online August 31, 1990.

Total Protein, Albumin and IgG Analysis of Serum and Cerebrospinal Fluid in Control and Aseptic Meningitis.

Nak Won Choi¹, Myung Ja Yoon¹, Hae Rung Chung¹, Dong Hyuk Kum¹

¹Department of Pediatrics, Koryo General Hospital, Seoul, Korea

Received: April 13, 1990;  Accepted: July 2, 1990.

Abstract

Determination of proteins in CSF and serum demonstrates two pathological conditions of CNS, namely a blood brain barrier (B.B.B.) damage and a selective elevation of IgG due to synthesis within CSF CNS. -Q albumin ratio is a sensitiv eand adequate parameter for demonstration of B.B.B. Serum CSF . „ / s^IgGratl0\ I pep \ damage and IgG Index = I Serum ) albumin ratio is a better measurement for local production of IgG within CNS. We analysed T. protein, albumin, IgG of CSF and serum using rate nephelometric ICS in 17 cases of aseptic meningitis compared to 18 cases of Controls who were admitted to Pediatric Dept, of koryo General Hospital from Oct. 1987 to July 1988. The results as follows; 1) Total protein in CSF was increased in aseptic meningitis (24.89 ±5.63 mg%) compared to those of control (35.6 ±12.41 mg%), but not in serum. 2) Albumin and IgG in CSF were significantly increased in aseptic meningitis (12.2±5.0 mg%, 1. 68±0.98 mg%) compared to those in control group (18.4±8.9 mg%, 2.88±1.64 mg%) (p<0.01). CSF 3) g규um albumin ratio was significantly increased in aseptic meningitis (0.0027 ±0.0005) compar- ed to those of control (0.0050±0.0032) (p<0.01). 4) IgG index was increased, but not significanlty, in aseptic meningitis (0.5304 ±0.0830) compared to those in control group (0.5459±0.1200) (p>0.01) This results suggest that aseptic meningitis damages a blood brain barrier, but does not synthesis IgG in CNS.

Keywords :Aseptic meningitis, albumin, IgG, IgG Index