All issues > Volume 33(6); 1990

Original Article

J Korean Pediatr Soc. 1990;33(6):762-771. Published online June 30, 1990.

A Study of C-Reactive Protein in Acute Infectious Diseases in Children.

H K Choi¹, Y H Chung¹

¹Department of Medicine, College of Medicine, Chungnam National University, Taejon, Korea

Received: November 21, 1989;  Accepted: February 14, 1990.

Abstract

The C-reactive protein is an abnormal protein, which is reacted to various non-specific stmuli such as infection, tissue necrosis, trauma, neoplasm and granuloma formation. Hence, C-reactive protein was index of infection and its allied diseases. Serum C-reactive protein determination on total 207 patients with infectious disease and allied conditions were done in the pediatric ward of Chungnnam National Hospital during the period from Jan, 1988 to March, 1989. The comparision with patient’s temperature, erythrocyte sedimentation rate, leukocyte count and differential count were made in those case. The results are as follows; 1. Positive rate of inflammatory parameters The high positive reaction in infectious diseases and allied conditions revealed CRP (68%), ESR (62%), and fever (59%) and the low positive reaction revealed leukocyte (31%), neutrophil (29%), stab (28%). 2. Positive rate of CRP 1) Positive reaction of CRP was not significantly different accoding to age interval(p>0.05). 2) The incidence of CRP positive rate was high in the sera of patients with bacterial infection and connective tissue diseases, but it was low in the sera of patients with viral infection. 3) The incidence and the intensity of CRP positive rate in the sera of patient with infections caused by staphylococcus, salmonella, streptococcus, E. Coli revealed higher than that caused by rota virus. 3. The Intensity changes of CRP 1) The degree of CRP was showed as follows; negative (32%), trace (5%), +1 (14%), +2 (11%), + 3 (18%), over +4 (20%). 2) The intensity of CRP in infectious diseases and allied conditions was showed that otits media, scarlet fever, bacterial meningitis, cellulitis, SBE, and JRA were higher than viral hepatitis, bronchial asthma, measles, viral exanthem, gastritis, cystitis. 3) According to increased intensity of CRP, ESR, leukocyte count and differential count were relatively correlated, but temperature was not. 4) The changes of CRP was decreased in the convalescent stage more than in the acute stage. 4. Relation between CRP and other parameters 1) At 仕le case of CRP positive reaction, there was showed as follows; elevated ESR (80%), leu- kocytosis (83%), netrophilia (77%), high fever (77%), increased stab (75%). 2) At the case of strong positive reaction (over+2 or +3), there was showed that the elevated ESR was related higher than others (over +3)，whereas the increased stab was related higher than others (over +2).

Keywords :C-Reactive protein