All issues > Volume 33(5); 1990

Original Article

J Korean Pediatr Soc. 1990;33(5):598-605. Published online May 31, 1990.

The Change of Anti-HBs Titer after Hepatitis B Vaccination in Newborn.

Ji Hye Kang¹, Young Mi Hong¹, Seung Joo Lee¹

¹Department of Pediatrics, Ewha Womans University, College of Medicine, Seoul, Korea

Received: September 29, 1989;  Accepted: November 15, 1989.

Abstract

Hepatitis B vaccination is an accepted preventive measure for all newborn as well as the risk group. However, there is some uncertainty about the persistence of anti-HBs and the timing of booster vaccination. We studied anti-HBs titer, positive rate and minimum protective rate in relation to time interval after the third vaccination in 102 infants bom to HBsAg negative mother (Group I) and 52 infants bom to HBsAg positive mother (Group II) from July, 1984 to December 1988. The results were as follows. 1) HBsAg was positive in 3% of 9392 pregnant woman 2) The titer of anti-HBs decreased significantly in relation to time interval after the third vaccina- tion. (p<0.05) 3) No significant difference in the mean anti-HBs titer, positive rate and minimum protective rate in relation to time interval between two groups suggested no effect of maternal HBsAg on the antibody response of offspring. 4) Anti-HBs positive rate and minimum protective rate were 98.4% and 85.2%, respectively in 1-12 rrwnths，but decreased rapidly after 36 months, to 68.4% and 47.4% in 37-48 months.

Keywords :Hepatitis B, Hepatitis vaccination on Newborn