All issues > Volume 33(4); 1990

Original Article

J Korean Pediatr Soc. 1990;33(4):506-513. Published online April 30, 1990.

Prognosis according to Etiology and Age at Diagnosis in Congenital Hypothyroidism.

Myoung Sook Nam¹, Young Jong Oh¹, Byung Hee Kim², Young Jong Woo², Young Youn Choi², Tai Ju Hwang²

¹Department of Pediatrics, St. Columban "s Hospital, Mokpo, Korea
²Department of Pediatrics, Chonnam University Hospital, Kwang Ju, Korea

Received: June 24, 1989;  Accepted: September 28, 1989.

Abstract

A retrospective study on patients with congenital hypothyroidism was undertaken. The following
results
were obtained from 17 patients, on whom follow up investigations were available. 1) Males outnumbered females. The etiologic classification revealed: thyroid agenesis (64.7%), dyshormonogenesis (23.5%), and ectopic thyroid (11.8%). 2) In two-thirds of cases the diagnosis were made under 1 year of age, with 23.5% of cases being diagnoses below 3 month and 41.2% between 4 to 12 month. The mean age at initial diagnosis was 1.2 year for thyroid agenesis, 2.7 year for dyshormonogenesis, and 8.5 year for ectopic thyroid. 3) Compared to the chronological age, both bone age (in 100%) and height age (in 70.6%) were below the 3rd percentiles. 4) Thyroid hormone study at initial diagnosis revealed that TSH was increased in all cases but the least in ectopic thyroid. Mean T in ectopic thyroid and T3 in dyshormonogenesis and ectopic thyroid were normal limits. 5) 4 in 11 cases of thyroid agenesis, 3 in 4 cases of ectopic thyroid had intelligence guotient (IQ) above 75 by modified Goodenough- Harris Drawing test. 6) Higher IQ values were anticip ated in the cases with higher T3 values or with lower TSH values at initial diagnosis.

Keywords :Congenital hypothyroidism, TSH, T3, T4, Intelligence quotient