All issues > Volume 33(2); 1990

Original Article

J Korean Pediatr Soc. 1990;33(2):252-258. Published online February 28, 1990.

A Case of Transient Myeloproliferative Disorder in Down's Syndrome.

Ji Hye Kang¹, Young Mi Hong¹, Kyung Hee Kim¹, Seung Joo Lee¹, Ki Sook Hong², Ok Kyung Kim², Je Geun Chi³

¹Department of Pediatrics, College of Medicine, Ewha Woman’s University, Seoul, Korea
²Department of Clinical Pathology, College of Medicine, Ewha Woman’s University, Seoul, Korea
³Department of Pathology, College of Medicine, Seoul Naitonal University, Seoul, Korea

Received: July 18, 1989;  Accepted: October 23, 1989.

Abstract

Transient myeloproliferative disorder has been reported in infant with Down's syndrome during neonatal period. This is clinically and hematologically indistinguishable from congenital acute leukemia. In contrast to congenital leukemia, complete clinical and hematological recovery occurs within weeks to months of diagnosis without antileukemic treatment. A neonate presented with jaundice, hepatosplenomegaly and mongoloid face was diagnosed as Transient myeloproliferative disorder. We report this case with a review of literature.

Keywords :Down’s Syndrome, Transient Myeloproliferative Disorder