All issues > Volume 33(1); 1990

Original Article

J Korean Pediatr Soc. 1990;33(1):59-65. Published online January 31, 1990.

E-Type Prostaglandin Therapy for Neonatal Cyanotic CHD.

Ah Young Yun¹, Jeong Yeon Choi¹, Yong Soo Yoon¹

¹Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea

Received: May 17, 1989;  Accepted: September 12, 1989.

Abstract

Between December 1987 and November 1988, Twenty infants with ductus-dependent congenital heart disease received intravenous infusion of PGE1 in the pediatric department of Seoul National University Hospital. Nineteen infants had cyanotic congtenital heart diseases and one had severe coarctation of aorta. Fifteen infants responded to PGE1 treatment and the mean Pa02 increased from 24 mmHg to 40 mmHg within one hour of infusion. Seven infants with preinfuson PaO2 less than 20 mmHg showed a greater increase in PaO2 than those with preinfusion PaO2 was one of the determinant of respon- siveness to PGE1. Pyrexia was the most common adverse effect of PGE1. Apnea occurred in 5 infants, 4 of whom were receiving PGE1 at a rate of 0.1 ug/kg/min. With infusion rate under 0.02 ug/kg/min, no serious side effects occured. We recommend the starting dose of PGE1 is 0.05 ug/kg/min and the dose should be reduced if increased PaO2 is maintained.

Keywords :Ductus dependent CHD, E-type prostaglandin