All issues > Volume 32(8); 1989

Original Article

J Korean Pediatr Soc. 1989;32(8):1123-1127. Published online August 31, 1989.

A Case of Patient with Common Variable Immunodeficiency.

Keun Cheon Kim¹, Chang Gee Kang¹, Chang Hyun Yang¹, Dong Soo Kim¹, Kir Young Kim¹

¹Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea

Received: January 25, 1989;  Accepted: March 24, 1989.

Abstract

Common variable immunodeficiency, as defined by World Health Organization classification of primary immunodeficiency, is a heterogenous group of disorders with hypogammaglobulinemia, decreased ability to produced antibody following antigenic challenge, and increased incidence of infections. The disorder was often familial, but no mode of inheritance has been discerned. Clinical fingings are recurrent bacterial infections, particularly respiratory infection. Laboratory evaluations in common variable immunodeficiency demonstrate decrease in th serum concentration of all major immunglobulin classes, IgG, IgM and IgA. T cell number and function may be abnormal and the ratio of T helper cell to T suppressor cell is reversed. We experienced a case of common variable immunodeficiency in a 7 year old boy who was admitted due to septic arthritis in left shoulder. This boy had typical clinical and labaratory features of common variable immunodeficiency. This case was discussed with a review of the literatures.

Keywords :Common Variable Immunodeficiency