All issues > Volume 32(8); 1989

Original Article

J Korean Pediatr Soc. 1989;32(8):1117-1222. Published online August 31, 1989.

Morphological Study of Cardiotoxicity in Adriamycin Treated Rats.

H W Shin¹, J Y Kim¹, C U Joo¹, P H Hwang¹, J S Kim¹

¹Department of Pediatrics, College of Medicine, Chonbug National University, Chonju, Korea

Received: January 25, 1989;  Accepted: March 7, 1989.

Abstract

This experiment was carried out to investigate the morphological changes of cardiac tissue in Adriamycin treated rats. Adriamycin was administered (2.5 mg/kg/wk) for 5 weeks, subcutaneously. Cardiac tissue stained by H-E and Trichrom’s method. Clinical findings of congestive heart failure were also observed during experiment. The results were as follows ； 1) Symptoms and signs of congestive heart failure (tachypnea, ascites, hepatomegaly) were appeared in 43% (6 out of 14 rats) of Adriamycin treated rats. 2) Histopathologic changes of myocardium were local and observed in subendocardial lesion of interventricular septum and anterolateral papillary muscle of left ventricle. 3) Histopathologic findings were hydrophic degenerative changes of myocardium and focal proliferation of fibrous tissue.

Keywords :Adriamycin, Histopathologic Finding, Cardiomyopathy