All issues > Volume 32(8); 1989

Original Article

J Korean Pediatr Soc. 1989;32(8):1057-1063. Published online August 31, 1989.

Clinical Study of Hypophosphatemic Rickets.

Seok Min Choi¹, Duk Hi Kim¹, Chin Suck Suh²

¹Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
²Department of Radiology, College of Medicine, Yonsei University, Seoul, Korea

Received: March 10, 1989;  Accepted: March 10, 1989.

Abstract

Hypophosphatemic rickets is a disorder characterized by a normal or slightly reduced serum calcium level, a moderately reduced serum phosphorus level and elevated alkaline phosphatase activity. The usual mode of inheritance is X-linked dominant and postulated mechanism is a selective disorder of tubular reabsorption of phosphate, defective conversion of 21-hydroxyvitamin D3 to calcitriol and increased catabolism of calcitriol. In children with renal hypophosphatemic rickets, growth failure is the clinical feature of major concern and the diagnosis is usually made only after significant growth retardation and bone deformity are evident. The combined administration of calcitriol and phosphate is currently the best and the most accepted treatment for renal hypophosphatemic rickets. We experienced 8 cases of hypophosphatemic rickets and report with a brief review of literatures.

Keywords :Hypophosphatemic Rickets