All issues > Volume 32(8); 1989

Original Article

J Korean Pediatr Soc. 1989;32(8):1051-1056. Published online August 31, 1989.

Serum LDH and Isoenzyme Activity in Children with Respiratory Diseases.

Kyoung Min Ann¹, Young Kyoo Shin¹, Kwang Chul Lee¹, Ji Tae Choung¹, Young Chang Tockgo¹, Pyung Hwa Choe¹

¹Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea

Received: July 10, 1989;  Accepted: July 10, 1989.

Abstract

LDH which are widely distributed in mammalian tissues, being rich in myocardium, kidney, liver and muscle, and which is well known to catalyzes the reversible oxidation of lactate to pyruvate. We investigated serum LDH & Isoenzyme changes in 317 cases of children with respiratory disease and in 117 cases of healthy children as control. The objectives of this study were to ascertain whether serum LDH changes with respiratory diseases. The results obtained were as follows. 1) The average serum LDH levels are 383 ±68 U/ml and showed decreasing tendency by age as follows: 571±91 U/ml in under one year old age group, 560±125 U/ml in 1 year, 429±107 U/ml in 2 year, 473 ±58 U/ml in 3 year, 444 ±84 U/ml in 4 year, 453 ±87 U/ml in 5 year, 458 ±95 U/ml in 6 year, 398±29 U/ml in 7 year, 361 ±51 U/ml in 8 year, 376+71 U/ml in 9 year, 393±88 U/ml in 10 year, 375± 45 U/ml in 11 year, 352±39 U/ml in 12 year and 310±52 U/ml in above 13 year respectively. 2) The average serum LDH levels in respiratory disease also showed decreasing tendency by age significantly (R<0.5). 3) Serum LDH levels are increased in pneumonia, especially in interstitial type than lobar type but there were no statistical difference between bronchitis, bronchiolitis, asthma and control. 4) Isoenzyme of LDH in pneumonia resulted slight increase in L2, L3 without statistical signifi- cance.

Keywords :Lactic Dehydrogenase, Isoenzyme, Respiratory Disease