All issues > Volume 32(7); 1989

Original Article

J Korean Pediatr Soc. 1989;32(7):915-925. Published online July 31, 1989.

Clinical Study of Interrelationship Between Cold Agglutinin Titers and Indirect Hemagglutination Titers in Children with Mycoplasma Pneumoniae Pneumonia During Recent 3 Years.

Jong Chan Shin¹, Jae Youn Kim¹, Myung Ik Lee¹, Soon Wha Kim¹, Keun Chan Sohn¹, Kyeung Eun Jung²

¹Department of Pediatrics, National Medical Center, Seoul, Korea
²Department of Bacteriology, National Medical Center, Seoul, Korea

Received: October 18, 1988;  Accepted: December 12, 1988.

Abstract

A clinical study was made on 103 cases of Mycoplasma pneumoniae pneumonia patients during the period of 3 years from July ’84 to June '87. Indirect hemagglutination test (IHA) and/or cold agglutinin test (CAT) were measured and follow-up studies were done until the 50th day of the illness. Each titer was compared for analysis of interrelationship between them. And we obtained following
results
1) The highest incidence of Mycoplasma pneumoniae pneumonia occurred in children of 3 to 6 years of age and the incidences were nearly same in both sexes. 2) Seasonal distribution showed increased occurrence in autumn. Forty-five cases (43.7% of all patients) occurred from September to November. B) The positive rate of CAT was divided into 10 groups at interval of 5 days. The positive rate was 30% within the 5th illness-day and 72% from the 6th to the 10th illness-day. Both titers were compared and we could observe that cold agglutinin titers raised significantly during the 10th illness-day (x2 = 6.462, p< 0.025). Thereafter positive rate was highest (82.4%) in the 16th to the 20th illness-day and decreased to 25% after the 41st illness-day. 4) The positive rate of IHA was also divided as the same method as above. The positive rate of IHA was also divided as the same method as above. The positive rate was 28% within the 5th illness-day and 78.3% in the 6th to the 10th illness-day. Both titers were compared and we could observe that indirect hemagglutinin titers raised significantly during the 10th illness-day (x2 = 5.693, p< 0.025). Thereafter positive rate was remained nearly 100% until the 45th illness-day and decreased to 60% after the 46th illness-day. 5) The children whose peak titers of CAT and IHA were determined through follow-up were grouped at interval of 3 days. There noted the highest occurrence from the 15th to the 17th illness-day both in CAT (40.7%) and IHA (41.9%). 6) We could observe statistically significant correlation between cold agglutinin titers and indirect hemagglutinin titers from the 6th to the 40th illness-day among the children who had been measured both titers at the same time (p< 0.001, N = 66, r=0.5190).

Keywords :Mycoplasma pneumoniae, Indirect hemagglutination test, Cold agglutinin test