All issues > Volume 32(6); 1989

Original Article

J Korean Pediatr Soc. 1989;32(6):789-796. Published online June 30, 1989.

Serum IgE Level in Patients with Minimal Change Nephrotic Syndrome.

Sung Oh Kim¹, Hee Jung Ahn¹, Seong Ho Kim¹, Woo Gill Lee¹

¹Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea

Received: November 28, 1988;  Accepted: November 28, 1988.

Abstract

It has been reported that many patients with minimal change nephrotic syndrome(MCNS) have high serum IgE level, but its significance has not been disclosed yet. In this study, serum levels of IgE were evaluated in different stages of the disease with or without treatment in 26 MCNS(proven by renal biopsy) patients admitted to the Department of Pediatrics Hanyang University Hospital from January, 1980 to April, 1988. The study showed higher serum levels of IgE in patients with MCNS than control. In comparison of serum IgE levels according to age group in nephrotic phase(regardless of initial attack or relapse) and in remission phase of MCNS, IgE levels were increased in all the age groups of nephrotic phase than control, and in remission phase IgE was increased in age groups of 1-5 year and of 6-9 year. No significant increase in age group over 10 year was noted In male patients, serum IgE levels of nephrotic phase and of remission phase, were higher than control, but in female, only nephrotic phase they were higher than control. There was significant difference between IgE levels during the nephrotic phase and remission phase of the disease. Steroid responders had higher serum levels of IgE than non-responders and dependents. In conclusion, it may be possible that serum IgE levels can be used as a predictive value for the clinical course of MCNS patients. However, because of variable serum IgE levels during follow-up studies, continuing studies of patients with MCNS will be necessary to clarify its significance of change in serum IgE levels.

Keywords :Serum IgE, Minimal change nephrotic syndrome