All issues > Volume 32(5); 1989

Original Article

J Korean Pediatr Soc. 1989;32(5):665-669. Published online May 31, 1989.

Cyclophosphamide-Induced Hemorrhagic Cystitis in Acute Lymphocytic Leukemia and Non-Hodgkin Lymphoma.

Young Seo Park¹, Il Soo Ha¹, Soon Ki Kim¹, Hae Il Jung¹, Yong Choi¹, Hyo Seop Ahn¹

¹Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea

Received: October 26, 1988;  Accepted: October 26, 1988.

Abstract

We studied the cyclophosphamide-induced hemorrhagic cystitis in 72 cases of acute lymphocytic leukemia or Non-Hodgkin lymphoma, which had been treated at Seoul National University Children' s Hospital from June, 1985 to May, 1988 1) Among 72 cases treated with cyclophosphamide, 6 cases(12.8%) developed hemorrhagic cystitis in 47 cases of acute lymphocytic leukemia and 2 cases(8.0%) in 25 cases of Non-Hodgkin lymphoma. 2) The development of hemorrhagic cystitis was not related to the dose of cyclophosphamide or the hydration during therapy but the symptoms were mild in the cases hydrated during therapy. 3) The hemorragic cystitis developed within 30 days after therapy except 1 case, and developed after first or second administration of cyclophosphamide. Therefore the risk of hemorrhagic cystitis seems to be high in early period of therapy. 4) The all cases of hemorrhagic cystitis were improved without complications or sequalae and the recurrence was absent in all cases after readministration of cyclophosphamide. But it will be necessary to follow up for long time.

Keywords :Cyclophosphamide, Hemorrhagic cystitis, Acute lymphocytic leukemia, Non-Hodgkin Lymphoma