All issues > Volume 32(2); 1989

Original Article

J Korean Pediatr Soc. 1989;32(2):262-269. Published online February 28, 1989.

A Case of Congenital Megakaryoblastic Leukemia Accompanied by Down Syndrome Which was Diagnosed by Autopsy Findings.

Il Kyung Kim¹, Dong Beom lee¹, Jung Sik Min¹, Chang Hee Choi¹, Je Geun Chi²

¹Department of Pediatric, Seoul Adrentist Hospital, Seoul, Korea
²Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea

Received: May 10, 1988;  Accepted: July 25, 1988.

Abstract

Many cases of acute megakaryonlastic leukemia have been reported in childhood or adults, but congenital form or the cases occuring in neonatal period is very rare throughout the world. In Korea only one case was reported previously by Chung et al in 1987. The authors experienced a case of congenital megakaryoblastic leukemia accompanied by Down' s syndrome, which was confirmed by autopsy and positive reaction tl anti-factor V III monoclonal antibody. We report this case with a review of literature.

Keywords :Congenital Megakaryoblastic Leukemia, Down’s syndrome