All issues > Volume 32(1); 1989

Original Article

J Korean Pediatr Soc. 1989;32(1):67-74. Published online January 31, 1989.

A Clinical Study of Henoch-Schönleln Purpura in Childhood.

Y S Choi¹, H J Kwon¹, H Seong¹, C H Choi¹

¹Department of Pediatrics, Seoul Adventist Hospital, Seoul, Korea

Received: May 10, 1988;  Accepted: August 16, 1988.

Abstract

The authors experinced 94 cases of Henoch-Schönlein purpura in chilhood during the period form January, 1981 to Junly, 1987. The summary of the clinical and laboratory observations are as follows. 1) Male to female ratio was 1.4 : 1 and the age distribution of Henonoch-Schönlein purpura in showed a peak incidence between 3 to 10 years of age (79%). 2) In seasonal incidence, the cases were frequent during Spring (35%) and Autumn (27%). 3) The previous history of upper respiratory tract in infection was noted in 40 cases (42% ), no specific history was noted in 26 cases (28% )and only 15 cases (16%) showed allergic history. 4) The main clinical manifestations were skin rash (100%), abdominal symptoms (96%), joint manifestations (57%) , and renal involvement (34 %). 5) The joint involvement was observed mostly on knee joint (70%)and ankle joint (44%). The arthritis with joint swelling was observed in 2/ 3 cases which showed arthritis. 6) As for the gastrointestinal symptoms, abdominal pain was most commonly (86%) observed and others were nausea and vomiting (46%), and occult blood (44%). 7) The renal involvement was observed in 32 cases (34%). The hematuria was seen in 100% of cases with renal involvement and the proteinuria in 78% of these. The improvement of renal manifestations were noted in 91 % of these cases within 4 months. The nephrotic syndrome was developed in 4 cases. 8) Hematologically, mild anemia (9-12 gm/ dl of Hb) was observed in 21 % of cases leukocytosis (over 10,000/ ㎣) in 63 % of cases, increased ESR (over 20 mm/ hr) in 45 % of cases, increased reticulocyte count (over 0.6%) 62% of cases, and increased platelet count (over 400,000/ /㎣) in 40 % of cases. In clotting studies including bleeding time, clotting time, prothrombin time were mostly within normal ranges. Positive ASO titer (over 250T odd unit) was observed in half of cases and positive C-reactie protein in 70% of cases. 9) Recovery of skin, abdominal and joint manifestations was observed mostly within 1 month.

Keywords :Henoch-Schönlein purpura