All issues > Volume 31(11); 1988

Original Article

J Korean Pediatr Soc. 1988;31(11):1445-1452. Published online November 30, 1988.

A Study on Coagulopathy in High-risk Neonates.

Chae Sup Yoo¹, H. W. Lee¹, Keun Lee¹, Moon Ja Kim²

¹Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea
²Department of Pediatrics, Incheon Red Cross Hospital, Incheon, korea

Received: November 14, 1987;  Accepted: July 25, 1988.

Abstract

Life threatening neonatal hemorrhage is a common problem in Nursery Intensive Care Unit. It is associated with asphyxia, intracranial hemorrhage, and hyaline membrane disease, and develops to D.I.C., which attributes to neonatal mortality and morbidity. Clinical study was performed on 32 high-risk neonates and 20 mild illness cases, who had been admitted to Department of Pediatrics, Ewha University Hospital, during the period of 2.6 years from January, 1985, to June, 1987. The examined coagulation studies were platelet, P.T., P.T.T., Fi- brinogen, and F.D.P. The follow-up studies were done at postnatal 48-72 hours, for treated 12 cases and the cases who showed initial abnormal data. The following results were obtained: 1) The coagulation studies which were done within postnatal 24hours showed abnormal platelet, P. T.，P.T.T., Fibrinogen, and F.D.P. in high-nisk neonates more often than mild cases. 2) 5 cases were expired. 4 cases had intracranial hemorrhage and 1 had hyaline membrane disease. There were clinical bleeding tendencies, and laboratory hypocoagulabilities in all cases. 3) Platelet concentrates, whole blood, or fresh frozen plasma were given to 12 cases, who developed clinical and laboratory improvement after treatment. 4) The laboratory abnormalities tended to correct spontaneously in non-treated patients, who had mildly abnormal laboratory data and no bleeding tenency.

Keywords :Coagulopathy