All issues > Volume 31(9); 1988

Original Article

J Korean Pediatr Soc. 1988;31(9):1133-1138. Published online September 30, 1988.

Effect of Adriamycin on Lipid Metabolismin Rats.

Chang Beom Shin¹, Sun Jun Kim¹, Chan Unng Joo¹, Dae Yeol Lee¹, Jung Soo Kim¹

¹Department of Pediatrics, Chonbuk National University, Medical School, Chonju, Korea

Received: February 1, 1988;  Accepted: March 24, 1988.

Abstract

This experiment was carried out to investigate the disturbance of lipid metabolism after long-term administration of adriamycin in rats (2.5 mg/kg/week for 5 weeks, S.C.). Changes of Serum lipids, GOT, GPT, LDH, albumin, BUN, and creatinine were investigated after administration of adriamycin. Clinical findings of congestive heart failure and changes of body weight were also observed during experiment. The results were as follows; 1) Serum triglyceride, total cholesterol, free cholesterol, HDL cholesterol were makkedly elevated after administration of adriamycin. 2) No significant differences were found in serum GOT, GPT, LDH, albumin, BUN, creatinine between control and adriamycin administered group. 3) All classes of lipoproteih were increased after administration of adriamycin compose to that of control group on lipoprotein electrophoretic analysis. 4) Symptoms and sings of congestive heart failure (tachypnea, ascites, hepatomegaly) were appeared in 6 rats (43%) in experimental group. These results suggest that adriamycin-induced cardiotoxicity is related to disturbance of lipid metabolism in rats.

Keywords :Adriamycin, Lipid Metabolism