All issues > Volume 31(9); 1988

Original Article

J Korean Pediatr Soc. 1988;31(9):1126-1132. Published online September 30, 1988.

Changes of Specific Immunogloblins Against Dihperia Toxoid After DPT Vaccination.

Byung Sook Park¹, Byung An Shim¹, Kyung Jin Shin¹, Soo Chul Cho¹, Jung Soo Kim¹

¹Department of Pediatrics, College of Medicine, Chonbuk National University, Jean Ju, Korea

Received: February 1, 1988;  Accepted: March 21, 1988.

Abstract

The present study was performed to define the humoral immune responses after DPT vaccination changes of diphteria specific IgG and IgM were evaluated suing ELISA method on 196 cases of 6 groups which were divided according to the frequency of DPT vaccination. Alum-precipitated diphtheria toxoid was used as antigen for ELISA. The results were as follows; 1) IgG was mainly involed in humoral immune responses against diphtheria toxoid after DPT vaccination. 2) At least 2 times of vaccination were required to obtain the significant increases of diphtheria specific IgG titer. The values of diphtheria specific IgG were remained for about 2 years after vaccination and decreased slowly thereafter. 3) The values of diphtheria specific IgG were similar in both primary (DPT 3 times) and booster group (DPT 4 times) for 2 years vaccination, but significantly decreased in primary group after 2 years of vaccination. 4) The values of diphtheria specific IgG were relatively lower in neonates than adults. These results suggest that the primary vaccination schedule in Korea seems to be reliable and continuous booster vaccination on adults might be required.

Keywords :DPT vaccination, Diphtheria specific immunoglobulin