All issues > Volume 31(8); 1988

Original Article

J Korean Pediatr Soc. 1988;31(8):1064-1070. Published online August 31, 1988.

A Case of Acute Megakaryoblastic Leukemia in Infant with Down's Syndrome.

Jung Soon Whang¹, Soon hee Kim¹, Moon Ja Kim¹, Keun Lee¹, Je Geun Chi²

¹Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea
²Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea

Received: October 30, 1987;  Accepted: March 16, 1988.

Abstract

Acute megakaryoblastic leukemia is an uncommonly recognized disorder that is characterized by rapidly progressive proliferation of atypical megakaryocytes and their precursor cells, and fatal course. Abnormalities in chromosome 21 may have a more than random relationship to acute megakaryoblastic leukemia. The authors reports a case of acute megakaryoblastic leukemia in a 2 month old female patient who was admitted for evaluation of hepatosplenomgaly. Multiple organ infiltration of atypical megakaryocytes were confirmed on autopsy. The chromosomal analysis revealed 21 trisomy.

Keywords :Acute Megakaryoblastic Leukemia, Down’s Syndrome