All issues > Volume 31(8); 1988

Original Article

J Korean Pediatr Soc. 1988;31(8):1021-1027. Published online August 31, 1988.

Plasma Renin Activity (PRA) in Peripheral Vein and Renal Veins in Normotensive Children with Cyanotic Congenital Heart Disease.

Sang Kyu Park¹, Hae Il Cheong¹, Chung Il Noh¹, Yong Soo Yun¹, Yong Choi¹, Kwang Wook Ko¹

¹Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea

Received: December 15, 1987;  Accepted: March 16, 1988.

Abstract

PRA’s in peripheral vein, both renal veins, and inferior vena cava (IVC) were measured in 25 normotensive children without renal disease undergoing cardiac catheterization for their underlying cyanotic congenital heart disease. And we presented the results as reference values/ranges of PRA in children. 1) There was no significant difference in PRA between both side renal veins at any absolute PRA levels with a mean ratio (RT/LT) of 0.97±0.22. 2) The mean PRA ratio of one renal vein with higher PRA level to the contralateral renal vein with lower PRA level (R/RC) was 1.19, and the 95% confidence limit was 1.0 to 1.59. And 3 children(12%) showed a ratio higher than 1.5 with a highest value of 1.68. 3) The increase in hematocrit correlated linearly with the increase in peripheral vein PRA, with a coefficient of correlation of 0.67 (p< 0.005). In conclusion, a more prudent judgment for the meaning of measured PRA’s should be needed in children with severe polycythemia.

Keywords :Plasma Renin Activity, Hematocrit, Blood Viscosity, Cyanotic Congenital Heart Disease.