All issues > Volume 31(8); 1988

Original Article

J Korean Pediatr Soc. 1988;31(8):999-1006. Published online August 31, 1988.

A Study of Maternal IgG Anti-A, B in ABO Hemolytic Disease of Newborn: Relation between Antibody titer in Mother and Clinical Severity in Neonate.

Chong Woo Bae¹, yong Mook Choi¹, Chang Il Ahn¹, Hyun Sook Chi²

¹Department of Pediatrics, School of Medicine, Kyung Hee University, Seoul, Korea
²Department of Clinical Pathology, School of Medicine, Kyung Hee University, Seoul, Korea

Received: December 18, 1987;  Accepted: March 6, 1988.

Abstract

Only IgG anti-A, or Anti-B cross the placenta and are responsible for the occurrence of ABO hemolytic disease of newbom(HDN). We have conducted the role of IgG anti-A or anti-B in mothers to occurrence and severity of the disease with were related to the level of antibodies in pathogenesis of ABO-HDN. This report presents the relation between the degree of bilirubin, hemoglobin concentration in ABO-HDN and IgG anti-A, or anti-B in their mother. Studied group were 29 cases of ABO-HDN who had positive direct antiglobulin test and positive IgG anti-A, or anti-B in their mother. The following results were obtained: 1) There were 220 neonates with hyperbilirubinemia among a series of 1618 total live births from June 1986 to May 1987 at KHUH. Studied group were 13.2% in 220 cases of hyperbilirubinemia of newborn. 2) There were 38 cases of ABO-HDN with negative direct antiglobulin test, 29 cases of ABO-HDN with positive direct antiglobulin test and IgG anti-A or B in mother, respectively. 3) The ratio of AO-HDN and BO-HDN was 1.4:1. 4) There were 2 cases of antibody titers below 1:512, 4 cases were >=1:512,17 cases were >=1:1024 and 6 cases were >=1:2048, respectively. 5) According to the neonatal bilirubin concentration and maternal antibody titers, mean and standard deviation of bilirubin concentration were 13.4 ± 0.6 mg/dl in group of below 1:512 titer, 14. 2±1.4 mg/dl in group of >=1:512 titer, 16.4±2.2 mg/dl in group of >=1:1024 and 19.5±2.3 mg/dl in group of >=1:2048 titer. There were significant correlation between the degree of hyperbilirubinemia and maternal IgG antibody. 6) There were no relation between degree of positive direct antiglobulin test, anemia and maternal IgG antibody.

Keywords :IgG anti-A,B, ABO-Hemoytic Disease of Newborn. Isoimmune Disease