All issues > Volume 31(4); 1988

Original Article

J Korean Pediatr Soc. 1988;31(4):482-491. Published online April 30, 1988.

Burkitt Lymphoma in Children.

Soo Jong Hong¹, Dong Kyu Jin¹, Hee Young Shin¹, Hyo Seop Ahn¹, Chang Yee Hong¹, Je G Chi²

¹Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
²Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea

Received: September 29, 1987;  Accepted: November 24, 1987.

Abstract

Seventeen cases of Burkitt lymphoma under 15 years of age who were admitted to Dept, of Ped., Seoul National University Hospital from Jan. 1979 to Dec. 1986 were reviewed and analysed. One hundred and six cases of non-Hodgkin lymphoma were seen during the same period. 1) Burkitt lymphoma accounted for 16% of non-Hodgkin lymphoma. 2) The age ranged from 10/12 year to 15 5/12 years, with mean age of 6 years. 3) The ratio of male to female was 3.3:1 and boys were more prevalent than girls. 4) Involed sites were abdomen in 14 cases, head and neck in 6 cases, ovary and uterus in 3 cases, CNS in 3 cases, bone in 1 case, pleural fluid in 4 cases, and ascites in 3 cases. 5) Clinical stage by Murphy’s classification consisted of 2 stage Ⅰ (11.8%), 2 stage Ⅱ(11.8%), 4 stage Ⅲ (23.5%), 9 stage Ⅳ (52.9%). 6) Bone marrow involvement at initial diagnosis was seen in 8 out of 17 cases (47.1%) and CNS involvement was seen in 2 out of 14 cases (14.3%). 7) Treatment consisted of 6 chemotherapy only, 6 chemotherapy and radiation therapy, and 3 surgery and chemotherapy and/or radiation therapy. Remission rate was 80% and relapse rate was 42%. The longest relapse free survival time was 4 4/12 years, and 4 cases survived over one year without relapse. Acute tumor lysis syndrome was seen in 8 cases, but 4 cases survived.

Keywords :Burkitt lymphoma, Non-Hodgkin lymphoma, COMP, Ziegler classification, Murphy classifi- cation, Acute tumor lysis syndrome, Relapse free survival time