All issues > Volume 31(2); 1988

Original Article

J Korean Pediatr Soc. 1988;31(2):220-226. Published online February 28, 1988.

A Study on Minimal Change Nephrotic Syndrome in Children.

Yong Choi¹, Hong Jin Lee¹, Hae Il Cheong¹, Kwang Wook Ko¹, Hyun Soon Lee², Yong Il Kim²

¹Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
²Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea

Received: September 4, 1987;

Abstract

To assess the clinical significance of histopathologic variants of minimal change nephrotic syn- drome (MCNS) by light microscopic findings, 148 biopsy proven MCNS patients, who were admitted to Seoul National University Hospital between the period from January 1976 to December 1986, were analyzed according to clinical findings, steroid responsiveness, and follow up status in relation to the pathologic variants. The followings are summary and conclusion. 1) Significantly larger proportion of patients with FGO had onset before 6 years of age. 2) Hematuria was more common in patients with FTC and MMH than with Nil and FGO. 3) Hypertension, selectivity index and elevated Scr at admission were not different among the categories. 4) Unresponsiveness to initial treatment was significantly more common in patients with FTC and MMH. However the differences in the proportions of subsequent nonresponders were not remarkable among the histological categories. 5) Five (3.8%) out of 148 paitients died during the follow up period. With the above findings, clinical significance of subgrouping histologic variants in MCNS seems to be less prominent as the follow up period is extended.

Keywords :Minimal Change Nephrotic Syndrome