All issues > Volume 31(2); 1988

Original Article

J Korean Pediatr Soc. 1988;31(2):212-219. Published online February 28, 1988.

The Role of Anitiplatelet Antibody and the Therapeutic Effect of High-Dose I.V. gamma-globulin in Childhood Idiopathic Thrombocytopenic Purpura.

Kyu Chul Choi¹, Sang Ho Park¹, Yong Mook Choi¹

¹Department of Pediatrics, School of Medicine, Kyung Hee University, Seoul, Korea

Received: September 3, 1987;

Abstract

Among 48 children with I.T.P (26 acute, 10 chronic and 12 undetermined), the antiplatelet antibody test (APA) was qualitatively studied by indirect immunofluorescent method in 34 patients of which only 25 patients (18 acute and 7 chronic) were able to follow-up. The overall positivity of APA was 36% and there was no relationship with disease chronicity. Intravenous r-globulin was given at a dose of 400 mg/kg/day for 5 days in 14 patients (11 acute and 3 chronic) and 13 patients showed response (10 complete and 3 partial responses). One patient with acute I.T.P. was not responded to I. V. r-globulin treatment, but showed complete response to following steroid treatment. The higher the initial platelet count, the better the response to I.V. r-globulin treatment (p < 0.05). The response rate within a week after initiating treatment was 92.8% in I.V. r-globulin treated group and 41.2% in steroids (p< 0.025). And the complete response rate of 76.9% was noted in I.V. r-globulin treated group and 35.7% in steroids (p < 0.05). The detection of APA was not useful in predicting response to certain treatment or selecting treatment method.

Keywords :Idiopathic thrombocytopenic purpura, Antiplatelet antibody, I.V. r-globulin.