All issues > Volume 31(1); 1988

Original Article

J Korean Pediatr Soc. 1988;31(1):106-112. Published online January 31, 1988.

6 Cases of Intracranial Hemorrhage due to late Late Hemorrhage Disease of Infancy.

Sang Ho Choi¹, Jae You Choi¹, Jee Sung Kim¹, Im Ju Kang¹

¹Department of Pediatrics, Fatima Hospital, Dae Gu, Korea

Received: September 23, 1987;

Abstract

A bleeding syndrome in early infancy due to vitamin K deficiency has been reported sporadically from various parts of world. The syndrome has similarities to hemorrhagic disease of newborn. The main differences are that it is found in an older age group, the pathogenesis is unknown, and intracranial hemorrhage are frequent with a resultant high mortality rate. We have experienced 6 cases of spontaneous intracranial hemorrhage in the absence of known trauma from 1 to 3 months of age. Coagulation studies showed marked prolongation of prothrombin time and partial thromboplastin time. Satisfactory clinical and laboratory results were demonstrated after vitamin K administration and fresh blood transfusion to correct the coagulation defect and anemia.

Keywords :Late hemorrhagic disease of infancy, Vitamin K deficiency, Intracranial hemorrhage