All issues > Volume 30(11); 1987

Original Article

J Korean Pediatr Soc. 1987;30(11):1311-1317. Published online November 30, 1987.

A Case of Systemic Lupus Erythematosus Accompanied with Nephritis and Arteritis.

Oh Kyun Kwon¹, Hong Yang Khil¹, Jae Ho Lee¹, Young Hun Chung¹

¹Department of Pediatrics, College of Medicine, Chungnam National University

Abstract

The systemic lupus erythematosus (SLE) is a chronic inflammatory disease involving skin, kidney, serous membrane, nervous system and other organs. We experienced a case of SLE accompanied with nephritis and arteritis on the region of the left thigh, diagnosed by clinical, serologic, immunologic, radiologic and pathologic evaluations. A 15 years old female patient was admitted to pediatric ward due to sustained pain on left thigh. She exhibited symmetric erythematous rashes on the face, intermittent moderate fever, enlarged cervical lymphnodes and hepatosplenomegaly on admission. The hematologic findings revealed anemia on peripheral blood and erythroid hyperplasia on bone marrow. The urine findings revealed proteinuira, hematuria and granular casts. The results of ANA, LE, VDRL and Commbs’ test were positive serologically and the level of C3 was 20 mg/dl. The femoral angiography showed decreased vascularity, beading of the vascular wall and narrowed vascular lumen on left side. There were massive granular deposits of the immune complex, complements and electron dense materials on renal bipsy specimen compatible with diffuse proliferative lupus glomerulonephritis (WHO Class IV).

Keywords :Systemic lupus erythematosus; Lupus nephritis; Vasculitis