All issues > Volume 30(7); 1987

Original Article

J Korean Pediatr Soc. 1987;30(7):735-741. Published online July 31, 1987.

Immunologic Function in Early Phase of Various Glomerulonephritis.

Soon Don Hong¹, Hyoung Soo Cho¹, Chang Il Ahn¹

¹Department of Pediatrics, Kyung Hee University, School of Medicine

Abstract

Abnormal lymphocyte function has been postulated to have a pathogenetic role in nephrotic syndrome. To assess immunologic parameters in the pathogenesis of various glomerulonephritis in early phase, in prdiatric department of Kyung Hee University Hospital from September 1985 to June 1986, serum immunoglobulin concentration and T cell subsets were measured in 32 children and compared with normal control group (n=30). Further studies are needed to evaluate immunologic parameters in glomerulonephritis, but our study shows as follows: 1) The OKT4/OKT8 ratio increased in post streptococcal glomerulonephritis, minimal change nephrotic syndrome and IgA nephropathy compared to normal control group, but statiscally no significance. 2) Serum IgG level was significantly reduced in minimal change nephrotic syndrome, but the others immunoglobulin level were within normal limit.

Keywords :0KT4; 0KT8; Immunoglobulin; Glomerulonephritis