All issues > Volume 30(5); 1987

Original Article

J Korean Pediatr Soc. 1987;30(5):504-510. Published online May 31, 1987.

Clinico-Hematologic Observation of Neonatal Hemolytic Disease due to Minor Blood Group Isoimmunization.

Chong Woo Bae¹, Yong Mook Choi¹, Chang Il Ahn¹, Hyun sok Chi²

¹Department of Pediatrics, School of Medicine, Kyung Hee University
²Department of Clinical Pathology, School of Medicine, Kyung Hee University

Abstract

The isoimmune hemolytic diseases of the newborn due to minor blood group are characterized by the abnormal titer of minor group antibody in mother’s serum and neonatal progressive jaundice caused by isoimmune hemolytic anemia. This report present the clinico-hematologic features of six cases of hemolytic diseases of newborn due to minor blood group isoimmunization who were admitted to the Kyung Hee university Hospital and presented with jaundice and anemia. The following results were obtained; 1) Neonatal jaundice was observed immediately after birth in 5 cases, the other one case aged 2.5 months was noted severse anemia on admission. 2) Total bilirubin levels were 12.5〜40.0 mg%. 3) On antiglobulin test, positive direct reaction were revealed in all cases of patient and positive indirect reaction were revealed in 5 cases of mother. 4) There was no evidence of ABO or Rh(D) incompatibility in all cases. All patients had E, c antigens in blood, but mothers had no E, c antigen in blood by Rh-Hr subtyping. 5) In summary, three cases of anti-E, 2 cases of anti-c and 1 cases of anti-E or c incompatibility were noted by selective antibody screening.

Keywords :Minor blood group; Isoimmune hemolytic disease; Neonatal hyperbilirubinemia