All issues > Volume 30(4); 1987

Original Article

J Korean Pediatr Soc. 1987;30(4):398-405. Published online April 30, 1987.

Studies on the Changes of Serum Osmolality Electrolytes, Digoxin-like Substance and Plasma Renin Activity Following Angiocardiography using Hypertonic Contrast Media.

Heon Seob Song¹, Hyeong Won Shin¹, Chan Uhung Joo¹, Dae Yeol Lee¹, Jin Gon Jun¹

¹Department of Pediatrics, Chonbuk National University Medical School

Abstract

Angiocardiography and cineangiocardiography have been employed with increasing frequency for the diagnosis of cardiovascular diseases. These commonplace technics of cardiovascular radiology depend upon the rapid injection of hypertonic contrast media into the heart or central circulation. In order to study the effects of concentrated radiopaque materials(Conray®, 1382 mOsm/L, 1-2 ml/ kg) on hemodynamic consequences, the changes of serum osmolality, sodium, potassium, chloride, digoxin-like substance and plasma renin activity were evaluated during angiocardiography on 25 cases of congenital heart disease. Blood samples were obtained before and 1, 5, 10, 15 minutes after angiocardiography. The results were as follows: 1) Serum osmolality was significantly increased until 5 minutes after angiocardiography(p < 0.05). 2) Serum sodium and hematocrit values were also significantly decreased until 1 minute after angiocardiography(p < 0.05), while serum potassium and chloride values were not. 3) The values of plasma renin activity were slightly decreased without significance(p > 0.05). 4) Digoxin-like substance was only detected in the patients administrated digoxin and was not detected at all in the patients not administrated digoxin. These results suggest that it is safe to wait at least 5 minutes until hemodynamic changes have returned to the preangiocardiographic level before proceeding with another injection.

Keywords :Angiocardiography;Digoxin-like substance;Plasma renin activity;Hypertonic contrast media.