All issues > Volume 30(2); 1987

Original Article

J Korean Pediatr Soc. 1987;30(2):223-228. Published online February 28, 1987.

A Case of Glanzmann's Thromboasthenia.

Hee Kyung Park¹, Kyung Hee Kim¹, Sang Man Shin¹, Sang Jhoo Lee¹

¹Dept, of Pediatrics, College of Medicine, Soon Cheon Hyang University

Abstract

Glanzmann’s Thromboasthenia is a rare autosomal recessive hemorrhagic disorder characterized by chronic nonthrombocytopenic purpura, a prolonged bleeding time, and deficient or absent clot retraction. The major underlying abnormality is defective first phase aggregation of platelets, which are unresponsive to ADP in any concentration. The authors experienced one case of Glanzmann’s Thromboasthenia in a 8 year 10 month old female, who had frequent epistaxis and gingival bleeding. Platelets of patient showed complete absence of aggregation in response to ADP, collagen and epinephrine. The review of the literature was made briefly.

Keywords :Thromboasthenia, Platelet aggregation.