All issues > Volume 30(1); 1987

Original Article

J Korean Pediatr Soc. 1987;30(1):80-88. Published online January 31, 1987.

A Clinical Study of Neuroblastoma.

Jung Sook Hong¹, Yang Dong Park¹, Il Whan Kim¹, Hyun Gi Jung¹, Jae Sun Park¹

¹Department of Pediatrics, Kosin Medical College, Gospel Hospital, Busan, Korea

Abstract

17 Cases of neuroblastoma diagnosed and treated at the Kosin Medical College from Mar. 1978 toFeb. 1985 were analyzed and the results are as follows: 1) Ages at the time of diagnosis were from 7 months to 9 years. The mean age was 3 10/12 years. 29.4% of the patients were below the age of 2 and 82.3% of the patients were below 5. 2) The sex ratio of male to female was 1.83:1. 3) The primary sites of 14 confirmed cases were the abdominal cavity (7), the mediastinum (4), the pelvic cavity (2), and the cervical region (1). Among the 7 cases whose primary sites were in the abdominal cavity, 5 of them were of adrenal origin and the others were of non-adrenal origin. In 3 cases the primary sites were unable to determine. 4) The most frequent sites of metastasis were bone and distant lymph node followed by liver, skin, bone marrow, orbit, pleura, brain and lung. 5) In the pathological analysis of the 17 cases, 15 cases were found to be neuroblastoma and 2 cases were ganglioneuroblastoma. 6) The commonly encountered symptoms and signs were abdominal mass (41.2%), abdominal pain, abdominal distention, nodular mass on head or neck and fever. 7) The distribution of patients according to Evans staging system were 1, 3 and 13 cases of stageII,III and IV, respectively. 8) The total peripheral lymphocytes count of 6 died patients was 2,776/mm3, and that of 3 survived beyond 2 years was 4,571/mm3. 9) The 2 year survival rate of 14 treated patients was 21.4% (3/14).

Keywords :Neuroblastoma, Ganglioneuroblastoma, 2 year survival rate.