All issues > Volume 29(10); 1986

Original Article

J Korean Pediatr Soc. 1986;29(10):1095-1103. Published online October 31, 1986.

Clinical Evaluation of Congenital Heart Disease in Down Syndrome.

Sang Kyu Park, Young Hoon Kim¹, Son Moon Shin¹, Chung Il Noh¹, Jung Yun Choi¹, Yong Soo Yun¹, Cang Yee Hong¹, Kyoo Wan Choi², Shin Yong Moon³

¹Department of Pediatrics. College of Medicine, Seoul National University
²Department of Internal Medicine, College of Medicine, Seoul National University
³Department of Obstetrics and Gynecology, College of Medicine, Seoul National University

Abstract

The association of congenital heart disease in patients with Down syndrome has been recognized for nearly 100 years. A wide variety of congenital heart diseases have been identified in these patients. This is the report of clinical evaluation of 105 patients with congenital heart disease in Down syndrome, experienced at the Seoul National University Hospital, during past 6 years from Jan. 1980 to Dec. 1985. The results of observations were as follows: 1) There were 105 patients(45.4%) with heart disease among 231 infants and children with Down syndrome. 2) The most common lesions were ventricular septal defect (48.6%), endocardial cushion defect(33.3%), tetralogy of Fallot(8.6%), secundum atrial septal defect(7.6%). 3) Nineteen acyanotic patients were catheterized; 17 patients(89.5%) had pulmonaryartery hypertension and 15 patients(79%) had pulmonary vascular obstruction. 4) 63 patients were followed up in these series, and among them 20 patients (31.7%) had died. The causes of death were pulmonary complication in ten cases, congestive heart failure in four cases.

Keywords :Congenital heart disease; Down syndrome.