All issues > Volume 29(9); 1986

Original Article

J Korean Pediatr Soc. 1986;29(9):948-953. Published online September 30, 1986.

Postnatal Changes of Serum Creatinine Levels in Neonates.

Jeong Wan Seo¹, Seung Joo Lee¹, Keun Lee¹

¹Department of Pediatrics, College of Medicine, Ewha womans University

Abstract

The concentration of creatinine, one of the simple and commonly used indices of glomerular filtration rate in children and adults, has been reported to be appreciably raised and variable during the first month of life. This study examined the effect of gestational age(G.A.) on the postnatal changes of creatinine in preterm and full-term neonates. The results were as follows; 1) The mean serum creatinine levels of preterm neonates(G.A. 29-33 weeks) were; 1. 31±0.39 mg/dl at 1 day, 1.06±0.31 mg/dl at 4 days, 1. 08±0.26 mg/dl at 7 days, 0.91±0. 21mg/dl at 14 days and 0.76+0.05 mg/dl at 21 days of age. 2) The mean serum creatinine levels of preterm neonates(G. A. 34-36 weeks) were; 1.16 ±0.41 mg/dl at 1 day, 0.92±0.23 mg/dl at 4 days, 0.82±0.27 mg/dl at 7 days, 0.76±0. 22mg/dl at 14 days and 0.77±0.13 mg/dl at 21 days of age. 3) The mean serum creatinine levels of full-term neonates(G.A. 37-41 weeks) were; L 18 ±0.36 mg/dl at 1 day, 0.80±0.25 mg/dl at 4 days, 0.70±0.16 mg/dl at 7 days and 0.70± 0.16 mg/dl at 14 days of age. 4) The serum creatinine levels during first 1 week decreased significantly in all numbers and more rapidly in full-term than in preterm(G.A. 29-33 weeks) newborns. (p<0.05). 5) The serum creatinine levels decreased significantly with increasing postnatal age in all preterm and fullterm neonates for first month(p<0.01).

Keywords :Serum creatinine; Neonate