All issues > Volume 29(2); 1986

Original Article

J Korean Pediatr Soc. 1986;29(2):143-151. Published online February 28, 1986.

Study on Clinical Findings and Histopathologic Types in Biopsy Proven Glomerular Diseases in Korean Children.

Jae Seung Lee¹, Young Cherl Lee¹, Pyung Kil Kim¹, Hyeon Joo Jeong², In Joon Choi²

¹Department of Pediatrics, College of Medicine, Yonsei University
²Department of Pathology, College of Medicine, Yonsei University

Abstract

A clinical and pathologic study was made on 360 cases of renal biopsies in children who were admitted to Severance Hospital, Yonsei University College of Medicine, from Jan. 1979 to Dec. 1984. 1) Among 360 cases, 250 cases were male and 110 cases were female. The sex ratio of male and female was 2.3 : 1. The distribution was from 1 6/12 years of age to 16 years of age, and the peak incidence occured at 7 years of age in 43 cases. 2) Histopathologic classification of glomerular diseases were minimal change nephrotic syndrome 96 cases (26.7%), Purpura nephritis 58 cases(16.1%), Mesangiopathy 52 cases (14.4%), Benign recurrent hematuria 51 cases(14.2%), Poststreptococcal acute glomerulonephritis 47 cases(13.1%), IgA nephropathy 25 cases(6.9%), Membrabous glomerulonephritis 20 cases(5.8%), Membranoproliferative glomerulonephritis 4 cases(1.1%), Focal glomerulosclerosis 3 cases (0.8%), Lupus nephritis 2 cases(0.6%) and Alport syndrome 1 case(0.3%). 3) Histopatholigic classification of Primary nephrotic syndrome were Minimal change nephrotic syndrome 97 cases(54.9%), Mesangiopathy 52 cases(29.7%), Membranous glomerulonephritis 20 cases(11.4%), Membranoproliferative glomerulonephritis 4 cases(2.3%) and Focal glomerulosclerosis 3 cases (1.7%). 4) Minimal change nephrotic syndrome differs from those with Mesangiopathy in low age onset, low serum albumin, low a2-globulin, high 24 hr. urine protein and highly selective index. Mesangiopathy was characterized in hypertension, low serum C3 level compared Minimal change nephrotic syndrome. 5) Membranous glomerulonephritis differs from those with Mesangiopathy in low serum albumin, non-selective index, high 24 hr. urine protein and high ratio of HBsAg( + ) but the incidence of hematuria was decreased. 6) Membranous glomerulonephritis differs from those with Minimal change nephrotic syndrome in increased incidence of hematuria, low serum Cs, increased serum creatinine, non-selective index and high ratio of HBsAg( + ).

Keywords :Biopsy proven glomerular diseases