All issues > Volume 29(1); 1986

Original Article

J Korean Pediatr Soc. 1986;29(1):32-44. Published online January 31, 1986.

A Study on Changes of Serum Prootein, Immunoglobulins, and Electrolyte Metabolism in Childhood Nephrotic Syndrome after Steroid Therapy.

Kyung Rae Moon¹, Chang Soo Ra¹

¹Department of Pediatrics, College of Medicine, Chosun University, Kwangju, Korea

Abstract

The author determined serum and 24hr urine protein(total protein and albumin), immunoglobulins(lgG, IgA, and IgM) and serum electrolytes(Na, K, Ca, P, Mg, and Cl) in 5 cases of childhood nephrotic syndrome before and after steroid therapy, until urinary excretion of protein was negative (remission).The results observed are summarized as follows; 1) Serum protein; Before treatment, the mean serum total protein and albumin levels were 4. O±O. 9 gm/dl and 2. 3±O. 2 gm/dl respectively. After remission, the levels of mean serum total protein and albumin were increased to 4. 9±O. 7 gm/dl and 2.3 0.2 gm/dl respectively. 2) Serum immunoglobulin; Before treatment, the mean serum IgG, IgA and IgM levels ere 390±210 mg/dl, 204±48 mg/dl and 249±61 mg/dl respectively. After remission, the levels of mean serum IgG, IgA and IgM were increased to 506±260 mg/dl, 238±51 mg/dl and 308±101 mg/dl respectively.3) Serum electrolyte a. Na. K, CI; Before treatment, the mean serum Na,K and Cllevels were 139±7 mEq/L, 4. 4±O. 4 mEq/L and 99±8 mEq/L respectively. After remission, the levels of mean serum Na, K and CI were 138±2 mEq/L, 4. I±O. 7 mEq/L and 99±5 mEq/L respectively. b. Ca, Mg, P; Before treatment, the mean serum Ca, K and P levels were 7. O±l. 1 mg/dl, 5. 7±1. 5 mf/dl and 3. O±l. 6 mEq/L respectively. After remission, the levels of the mean serum Ca, Mg and P were 7. 9±O. 9 mg/dl, 4. 2±1. 7 mg/dl and 2. 9±O. 9 mEq/L respectively. 4) Urine protein; Eefore treatment, the 24 hr urine protein and albumin were 4.3::t4.1 gm/24 hr and 2. 2±1. 4 gm/24 hr respectively. The mean duration of remission was 9 days (range; 6-12days). 5) Urine immunoglcbulins; Before treatment, the mean 24 hr urine IgG and IgA were 403±448 mg/24 hr and 151 192 mg/24hr respectively, however IgM was not detected in theurine.

Keywords :Nephrotic syndrome; Serum and urine protein; lmmunoglobulin; Electrolyte