All issues > Volume 28(12); 1985

Original Article

J Korean Pediatr Soc. 1985;28(12):1190-1195. Published online December 31, 1985.

Lipid Composition of Serum HDL and Fatty Acid Composition of Serum Cholesteryl Esters in Newborn.

Jung Hee Kim¹, Dong Wook Kim¹, Dae Deok Ahn¹, Jung Kwon Lee¹, Yoon Ja Kim¹, Jung Chull Kim², Tai Ho Chung²

¹Department of Pediatrics, Catholic Hospital, Taegu,Korea
²Department of Biochemistry, Kyungpook National University, School of Medicine, Taegu,Korea

Abstract

Lipid consumption in early life has been implicated with atherosclerosis in later life. It has been also claimed that lipids contents of serum in early life would reflect coronary atherosclerosis in later life. Present study has undertaken to look for the composition of serum HDL and fatty acid composition of serum cholesteryl esters in newborns. Levels of high density lipoprotein (HDL) cholesterol, HDL-triglycerides, and HDL-phospholipids were determined after elimination of low density and very low density lipoproteins by sodium phophotungstate-Mg precipitation procedure. Fatty acid composition of serum cholesteryl esters was measured by gas-liquid chromatographic method. In comparison with adults, HDL-G, HDL-TG, concentration were decreased, but HDL-PL was significantly increased. However HDL-C/TC, HDL-TG/TG, and HDL-PL/PL ratio were significantly increased compared with those of adults. The statistically significant decrease in 18 : 2/18 : 2 ratio was observed in serum cholesteryl esters of newborns.

Keywords :Newborn; HDL; Fatty acid