All issues > Volume 28(9); 1985

Original Article

J Korean Pediatr Soc. 1985;28(9):899-905. Published online September 30, 1985.

Influence of Isoproterenol on the Plasma Renin Activity in Rats.

Woong Kyou Park¹, Yong Bae Shin¹, In soo Choi¹, Hyeon Suk Lee¹, Jung Soo Kim¹, Kyung Woo Cho²

¹Department of Pediatrics, Jeonbug National University,Medical School
²Department of Physiology, Jeonbug National University,Medical School

Abstract

It has been suggested that the effect of catecholamine administered into the renal artery on the plasma renin activity may be controlled by extrarenal beta-receptor. Still the exact mechanism responsible for the increase of the plasma renin activity by catecholamines is obscure. In this experiment I have intended to clarify the involvement of extrarenal beta-receptor concerning renin release in the rat. Systemic intravenous or intrarenal arterial infusion of isoproterenol increased plasma renin activity. The responses were dose dependent. Intrarenal areterial infusion of isoproterenol increased plasma renin activity less than the intravenous doses4 The difference of the responses between intrarenal and intravenous isoproterenol was found in the Wistar rat. The difference was not significant in the Sprague-Dawley rats. The above results suggest that the rat model is reasonable to the investigate the extrarenal beta-receptor controlling renin release, and that there are strain variations in the extrarenal or intrarenal or intrarenal betareceptor concerning renin release.

Keywords :Isoproterenol; Plasma renin activity