All issues > Volume 28(8); 1985

Case Report

J Korean Pediatr Soc. 1985;28(8):805-811. Published online August 31, 1985.

A Case of Acute Lymphocytic Leukemia Successfully Treated with Allogeneic Bone Marrow Transplantaion.

In Kyung Sung¹, Byung Churl Lee¹, Kyong Su Lee¹, Du Bong Lee¹, Chong Won Park², Chun Choo Kim², Dong Jip Kim²

¹Dept, of Pediatrics, Catholic Medical College,Seoul, Korea
²Dept, of Internal Medicine, Catholic Medical College,Seoul, Korea

Abstract

A 8-year old boy with acute lymphocytic leukemia who had shown resistance to repeated combination chemotherapies, was successfully grafted with bone marrow from his HLA- matched sister. He was in the third partial remission at the time of bone marrow transplantation. He was conditioned with cyclophosphamide 60 mg/kg/day on two consecutive days, followed by 800 rads total body irradiation. Marrow cells(2.4 X 10/kg) were infused intravenously 21 hours after total body irradiation. Successful engraftment has been demonstrated karyotypically(sex chromosome of peripheral leukocytes) on the post-BMT 14 th day. To prevent graft-versus-host disease, he recieved methotrexate and prednisone after BMT. But, grade I~ I acute graft-versus-host disease had been developed. It was well controlled with intravenous prednisone. Now, one year after BMT, he has been well in complete remission without evidence of leukemic relapse or interstitial pneumonitis.

Keywords :Bone marrow transplantation; Allogeneic; Acute lymphocytic leukemia