All issues > Volume 28(8); 1985

Original Article

J Korean Pediatr Soc. 1985;28(8):741-750. Published online August 31, 1985.

A Study on Serum Creatinine and BUN Levels in Newborn Infants.

Shin Chung Jee, Chang Soo Ra

¹Department of Pediatrics, College of Medicine, Chosun University, Kwang ju,Korea

Abstract

The concept of renal function in the neonate has been that the developing kidney is immature and that glomerular and tubular functions are low for body size as compared with the adult. Authors determined the serum creatinine and blood urea nitrogen (BUN) levels of cord blood in 57 newborn infants(42 normal full-term and 15 premature infants) with gestational age of 28 to 42 weeks and their mothers at delivery. Serum creatinine levels were determined by the method using picric acid(Gilchem creatinine reagent, Gilford Diagnostics, USA) and serum BUN levels were determined by the urease method (A-Gent BUN reagent, Abbott Laboratories Diagnostic Division, USA). The following results were obtained; 1)The mean serum BUN level of cord blood in 42 normal full-term infants was 9.67+ 3.42 mg/dl and that level in 42 their mothers was 9.81±5.20 mg/dl. In comparison of the mean serum BUN level between the normal full-term and their mothers, no significant differences were observed. 2)The mean serum BUN level of cord blood in 15 premature in fants was 11.30±5.21 mg/dl. In comparison of the mean serum BUN level between the normal full-term and premature infants, no significant differences were observed. 3)The mean serum creatinine level of cord blood in 42 normal full-term infants was 0.55 ±0.24 mg/dl and that level in 42 their mothers was 0.66±0.26 mg/dl. In comparison of the mean serum creatinine level between the normal full-term infants and their mothers, the mean serum creatinine level of the mothers was significantly higher than that level of their newborn infants(p<0* 05). 4)The mean serum creatinine level of cord blood in 15 premature infants was 0.46±0.28 mg/dl and that level in 15 their mothers was 0.45±0.30 mg/dl. In comparison of the mean serum creatinine level between the premature and normal full-term infants, no significant differences were observed. 5) The correlation of serum BUN level between the newborn infants and the the mothers was statistically significant(Y=0.42x+5.27, r=0.74, p<0.05). However the correlation of serum creatinine level between the newborn infants and the mothers was statistically non-significant (Y=0. 42x+0.30, r=0.45, p<0.1).

Keywords :Serum creatinine; BUN; Newborn infants