All issues > Volume 28(5); 1985

Original Article

J Korean Pediatr Soc. 1985;28(5):455-462. Published online May 31, 1985.

Clinical Studies on Hepatotoxicity of Antituberculous Durgs in Children.

Seong Sook Kim, Ki Sup Chung

¹Department of Pediatrics,Yonsei University Medical Center

Abstract

A clinical studies were performed on hepatotoxicity of antituberculous drugs in 155 cases of tuberculous patients under 15 years who had been admitted to Pediatric Department of Yonsei University Medical Center during 4 years period between January, 1979 and December, 1982. The results were obtained as follows; 1) Hepatotoxicities were observed on 20 cases among 155 cases. They all belonged to the group taken isoniazid(INH) and rifampicin(RIF)-containing drug regimens, so they constituted 17% among the group(117 cases) taken INH and RIF-containing drug regimens. No patient treated with non RIF-containing regimens showed hepatotoxicity. 2) Among 117 cases taken INH and RIF-containing drug regimens, mild tuberculous infections(primary pulmonary tuberculosis, lymphatic tuberculosis) were 20 cases, among them 2 casesfio%) showed hapatotoxicity, whereas severe tuberculous infections(multiple organ involvement, progressive pulmonary tuberculosis, tuberculous meningitis, bone and joint tuberulosis, et al) were 97 cases, among them 18 cases(19%) showed hepatotoxicity. 3) Hepatotoxicity was found in 14 cases(18%) among 79 patients taken higher dose(more t- han 16 mg/kg/day) of INH and RIF, whereas 3 cases(16%) among 18 patients taken lower dose(less than 15 mg/kg/day).

Keywords :Antituberculous drugs; Hepatotoxicity