All issues > Volume 28(4); 1985

Case Report

J Korean Pediatr Soc. 1985;28(4):405-410. Published online April 30, 1985.

A Case of Hutchinson-Gilford Progeria Syndrome.

Seon Ock Khang, Jung Hee Lee, In Joon Seol, Gwi Jong Choi, Keun Soo Lee

¹Department of Pediatrics, School of Medicine, Hanyang University, Seoul, Korea

Abstract

Hutchinson-Gilford progeria syndrome is a rare genetic disease of unknown etiology with some features suggestive of accelerated aging. Patients with this disorder are usually of average intelligence and appear clinically normal at birth. However, in early childhood they develop severe growth retardation and a senescent phenotype, including balding, aged-appe-aring skin, generalized atherosclerosis, and strokes. They die prematurely as a result of myocardial infarction with on average age of 13. Authors presented a case of Hutchinson-Gilford progeria syndrome with brief review of the literatures.

Keywords :Hutchinson-Gilford progeria syndrome