All issues > Volume 28(4); 1985

Original Article

J Korean Pediatr Soc. 1985;28(4):386-389. Published online April 30, 1985.

A Case Report of Ventricular Septal Defect and Aortic Valve Insufficiency Occurred in Siblings.

K H Kim, S S Kim, J H Sul, S K Lee, D S Chin

¹Department of Pediatrics, College of Medicine,Yonsei University

Abstract

The occurrence of congenital heart disease can be explained by genetic or environmental aspects. But these factors act separately only in about 10% and most of all, which reaches up to 90%, are inherited by the pattern of multifactorial inheritance, in which there is an underlying genetic predisition, usually produced by the small effects of many genes interacting with an environmental triggers(chemical, drug, virus). The recurrence rate of same congenital heart disease is 2〜10% and it approximates the root of prevalence rate in general population in each defeet. These cases are familial recurrence in male siblings, in which cases ventricular septal defects were associated with aortic insufficiency and at the sames time right side inguinal hernias were combined in both patients.

Keywords :Congenital Heart disease; Multifactorial inheritance