All issues > Volume 28(4); 1985

Original Article

J Korean Pediatr Soc. 1985;28(4):378-385. Published online April 30, 1985.

Clinical Studies on Congenital Malformation.

Jung Hwan Choi, Hun Jong Chung, Chong Ku Yun

¹Department of Pediatrics, College of Medicine, Seoul National Universityt Seoul, Korea

Abstract

Although pediatrics has been advanced progressively in the past years, congenital malformations are known as a major cause of neonatal death. In spite of every efforts of pediatricians and obstetricians to exclude the possible factors of congenital malformations by antenatal care, the general incidence of congenital malformations has not been decreased yet. So, we surveyed the incidence of congenital malformations and its relation to antenatal factors. During the period of 3 8/i2 years, between June, 1980 and February, 1984, 6,583 deliveries at SNUH were studied on the basis of neonatal records and delivery notes, which were included the findings of the inspection, palpation, auscultation, radiologic study, chromosomal study at birth and autopsy findings. The results were as follows: 1)The incidence of congenital malformations among 6,583 deliveries was 3.08%(3.07% among live births and 3.59%, among still births). 2)Sex distribution(male to female) among malformed babies was 56 : 44. 3)The incidence of congenital malformations among the babies, over 2,500 g of birth weight, was 2.03% and 8.03%, among the babies, below 2,5000 S of birth weight. The differences between them was statistically significant(p<0.01). 4)The incidence of congenital malformations among the babies, over 38 wks, was 2.76%, and 7.94% among the babies, below 38 wks. The diffences between them was statistically significant(p<0.01). 5) The incidence of congenital malformations among the babies whose maternal age was over 35 years old was higher than that of the babies whose maternal age was below 35 years old(p<0.05). 6) Among 232 malformed babies, 28(13.7%) babies had more than one malformation. Two congenital malformalions in one system was most frequent(53.6%). 7)Among 232 malformations, 52 malformations,(22.4%) were in the cardiovascular system, 46(19.8%) in the musculoskeletal system, and 40(17.3%) in the gastrointestinal tract. 8)The systems of congenital malformations which were caused to neonatal death were CNS(44%), G-I tract(24%), cardiovascular system(20%)> musculoskeletal system(8%), and others(4%) in order of frequency. 9) The congenital malformations, which were caused to neonatal death, were anencephaly (32%), congenital heart disease(20%), craniopagus, cleft palate, cleft lip, umbilical herna, club foot, Pierre-Robin Syndrome. Polydactyly, in order of frequency. 10)Among 232 malformed babies, 127 babies(54.7%) had major malformation and 105 babies(45,3%) had minor malformation.

Keywords :Congenital Malformations