All issues > Volume 28(3); 1985

Original Article

J Korean Pediatr Soc. 1985;28(3):225-235. Published online March 31, 1985.

A Clinical Study on Neonatal seizures.

Chong Young Park, Myung Kul Yun, Jung Hwan Choi, Yong Seung Hwang, Chong Ku Yun

¹Department of Pediatrics, College of Medicine,Seoul National University

Abstract

Clinical Observations were made on 96 cases of neonatal seizure who were admitted to the Department of Pediatrics, Seoul National University Hospital during the period of 5 years from June, 1979 to May, 1984. The results were as follows: 1)The most frequent cause of neonatal seizure was sepsis with or without meningitis (27.4%), and followed by hypocalcemia(23.4%)> hypoxic-ischemic brain damage(12.9%), hypoglycemia(8.0%), intracranial hemorrhage( 5.7%), hypernatremia(5.7%) and meningitis (4.0%) in order of frequency. 2)The onset of 36 cases(29%) of neonatal seizure appeared within 24 hours of life, 19 cases(15.3%) in 2nd day and 9 cases(7.3%) in 3rd day. Two-third of neonatal seizure occurred within 7 days of life. 3)The most frequent type of neonatal seizure was subtle(47.9%) and followed by generalized tonic(26%), multifocal clonic(18.8%) and clonic(3.1%) in order of frequency. 4)The brain C-T were performed in 15 cases. They showed intracranial hemorrhage in 6 cases, generalized atrophy of cerebral hemisphere in 3 cases, massive hydrocephalus and ventriculitis, cerebral multiple infarct and frontal edema in 1 case, respectively, and there were no evidences of abnormality in 3 cases. 5)As the results of treatment, 62 cases(64.6%) of neonatal seizure were discharged in the state of improvement, 25 cases(26%) were discharged against medical advice and 9 cases (9.4%) expired. 6)The most favorable outcome resulted from neonates with hypocalcemia(improved in93.1%) and the worst outcome resulted from neonates with intracranial hemorrhage(improved in 14.3%). 7)The follow-up visits were made on 48 patients(50%) during the period from 3 days to 4 years. Fourteen cases(26.4%) showed neurologic sequelae which were cerebral palsy in 12 cases(22.6%) and frequent seizure in 2 cases(3.8%) and 1 case expired.

Keywords :Neonatal seizures