All issues > Volume 27(12); 1984

Original Article

J Korean Pediatr Soc. 1984;27(12):1151-1161. Published online December 31, 1984.

Clinical Study of the role of Exchange Transfusion for Treatment in Neonatal DIC.

Myung Shik Lee¹, Jin Sung Lee¹, Chul Lee¹, Dong Gwan Han¹

¹Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea

Abstract

This study was made of 9 cases of neonatal septicemia complicated with DIC and sclerema, who were admitted to the pediatric department of YUMC from January 1981 to June 1983. The following results were obtained; 1) A higher incidence was observed in males(77.8%), low birth weight(66.7%) and1 pretnature(77.8%). 2) The mean onset of sepsis was noticsd on 4.4 days of life. The most common presenting symptoms and signs were poor Moro reflex, poor feeding lethargy and jaundice. 3) More than 3 abnormal laboratory findings were shown in all neonates in the DIC study including platelet count, PT, PTT, Fibrinogen and FDP. Positive blood cultures were found in 7 cases and the 2 cases with negative blood culture resulting in DIC were suspected to result from asphyxia and hypothermia. 4) Associated diseases were DIC, sepsis, asphyxia, sclerema, meningitis and RDS etc. 5) Survival rate was 44.4%. Considering the above results, exchange transfusion may be effective as supportive therapy in neonatal septicemia complicated with DIC and sclerema which did not responded to antibiotic treatment.

Keywords :Exchang transfusion; NeonatalJDIC; Neonatal septicemia.