All issues > Volume 27(11); 1984

Original Article

J Korean Pediatr Soc. 1984;27(11):1088-1096. Published online November 30, 1984.

A Clinical Study of Reye`s Syndrome.

Young Seo Park¹, Hwan Jong Lee¹, Sang Pok Suk¹, Jeong Kee Seo¹, Kwang Wook Ko¹

¹Dept, of Pediatrics，College of Medicine，Seoul National University

Abstract

Seventy-four cases of Reye’s syndrome, diagnosed during the period of 1978-1983 at the Pediatric ward of Seoul National University Hospital, were studied on the clinical features and laboratory findings. The following results were obtained; 1) The annual incidence was increasing year by year and the monthly incidence was highest in September. 2) The sex ratio of male to female was 1.2:1. The highest incidence was showed between 7 and 12 months of age, and most of cases(73%) were under the 2 years of age. 3) The prodromal illness was present in 89% of cases. 4) The main clinical symptoms were disturbed consciousness(100%), vomiting(54%). fever (54%), hyperpnea(54%), seizure (53%) and diarrhea(6%). The hepatomegaly was noticed in 41% of cases and the mild jaundice was noticed in 6% of cases. 5) According to Lovejoy’s classification, the majority of cases were in stage H or above on admission (64%). The higher the stage, the higher the mortality. 6) The mortality was high in patients with the following laboratory findings. a) GOT≧300U/L b) LDH≧500 IU/L c) Ammonia>300 microgm/dl 7) The average mortality was 53%.

Keywords :Reye’s Syndrome.