All issues > Volume 27(7); 1984

Original Article

J Korean Pediatr Soc. 1984;27(7):664-672. Published online July 31, 1984.

Hepatobiliary Scintigraphy with 99mTc-DISIDA in the Evaluation of Neonatal Jaundice.

Kwang Soo Hwang¹, Sae Jin Lee¹, Kyung Sook Cho¹, Chong Dae Cho¹, Bok Hwan Park²

¹Department of Pediatrics, Maryknoll Hospital, Busan, Korea
²Department of Radiology, Maryknoll Hospital, Busan, Korea

Abstract

Hepatobiliary scintigraphy with 99mTc-DISIDA was used to evaluate neonates with direct hyperbilirubinemia who were admitted to the department of Pediatrics, Maryknoll hospital, between May 1981 and Jun. 1983. 1)Total number of patients were 10, boys to girls ratio was 4:1, and age distribution ranging from 9 to 200 days of age. 2)Initial studies of the seven patients intrahepatic cholestasis showed definite excretion into the intestinal tract in two, delayed excretion in four, and visualization of gallbladder only in one case. 3)Three patients with biliary atresia showed no evidence of excretion of the tracer into the gallbladder and intestinal tract. 4)Serum transaminase levels, GOT were from 30 units to 600 units and GPT were from 12 units to 283 units. Of the six patients with abnormal findings, one was biliary atresia and of the four patients with normal findings, two were neonatal jaundice. There was no correlation between transaminase level and neonatal hepatitis. 5)Serum Aik. P. levels were from 5.6 units to 32 units. Of the eight patients with abnormal findings, one was biliary atresia and of the two patients with normal findings, all were biliary atresia also. There was no correlation between Aik. P. level and biliary atresia. The authors conclude that serum GOT/GPT and Aik. P. levels are less accurate tests for differentiating biliary atresia from other causes of neonatal jaundice and that hepatobiliary scintigraphy with 99raTc-DISIDA is a highly accurate test.

Keywords :Radionuclide imaging; Biliary tract; Neonatal jaundice; Biliary atresia; Neonatal hepatitis