All issues > Volume 27(6); 1984

Original Article

J Korean Pediatr Soc. 1984;27(6):548-553. Published online June 30, 1984.

Change of Renal Excretion of Ascorbic Acid in Children.

Chang Yeal Jeon¹, Jong Duck Kim¹, Heon Sook Lee¹, Jung Soo Kim¹, Kyung Woo Cho²

¹Dept, of Pediatrics, Jeonbug National University, Medical School
²Dept, of Physiology, Jeonbug National University, Medical School

Abstract

In order to investigate the development of renal function, especially of the capacity of reabsorption of ascorbic acid in proximal tubule, in function of aging, experiments have been done. 1)Urinary flow, creatinine and electrolytes excretion in children (age :1~13yrs, weight: 10~39 kg) increased by aging and reached near the adult value at 11~13 years old. 2) Urinary concentration ability was matured at 3~5 years old. 3) Urinary phosphate excretion corrected by GFR decreased by aging and reached near the adult value at 11~13 years old. 4)Urinary ascorbic acid excretion corrected by GFR decreased by aging and this pattern was correlated with UporV/Ucr.V. These results suggest that proximal tubular function for the reabsorption of ascorbic acid may be well developed until the age of 11~13 years.

Keywords :Ascorbic acid; Urine