All issues > Volume 27(5); 1984

Case Report

J Korean Pediatr Soc. 1984;27(5):506-510. Published online May 31, 1984.

Rifampin Induced Nonresponsiveness to Steroid Therapy in Children with Minimal Change Nephrotic Syndrome .

Hae Il Cheong, Sang Bok Suk, Yong Choi, Kwang Wook Ko

¹Dept, of Pediatrics, College of Medicine, Seoul National University

Abstract

We experienced three children with the biopsy proven minimal change nephrotic syndrome who had failed to respond to prednisolone, 60 mg/m2/d for 4 to 9 weeks due to concomittent administration of rifampin. Because rifampin is a known enzyme inducer of the liver like phenobarbital and dilantin which can increase the clearance of the other drugs such as steroid etc., rifampin were discontinued after the admission to our Hospital. All three patients responded to the same dose of prednisolone 7 to 9 days after the withdrawal of rifampin. We report here the clinical and laboratory data of these patients along with brief review of the literatures.

Keywords :Minimal change nephrotic syndrome; Nonresponsiveness to steroid therapy;RFP-steroid interaction