All issues > Volume 27(5); 1984

Original Article

J Korean Pediatr Soc. 1984;27(5):475-482. Published online May 31, 1984.

Clinical Study of Cerebrospinal Fluid Lactate Levels in Children with Menigitis.

Sang Hee Cho, Ha Baik Lee, Keun Soo Lee

¹Department of Pediatrics, Hanyang University, College of Medicine, Seoul, Korea

Abstract

Cerebrospinal fluid lactate level and C-reactive protein(CRP) reactions were studied in 131 children who were hospitalized to the Department of Pediatrics, Hanyang University Hospital between February 1983 and August 1983. Among 131 hospitalized children, 68 were meningitis cases as for study group and the rest 63 were non-meningitis cases as for control group. These two groups were statistically well matched. The results were as follows: 1)Cerebrospinal fluid lactate levels in control group were 18.70土4.00 mg/dl. 2) Cerebrospinal fluid lactate levels in aseptic meningitis group were 26.22±6.79 mg/dl and this values were significantly elevated to compare with that of control group(p<0.01). 3)Cerebrospinal fluid lactate levels in tuberculous meningitis group were 69.48±17.82 mg/ dl and this values were significantly elevated to compare with that of both control and aseptic meningitis groups(p<0.01, in both). 4)Cerebrospinal fluid lactate levels in purulent meningitis group were 112.83±28.97 mg/dl and this values were highest among all groups(p<0.01). 5) Elevated CSF lactate levels were returned to normal after 4 to 6 days, 30 days and 3 days treatment in purulent meningitis group, tuberculous meningitis group and aseptic meningitis group, respectively. 6)The positivity rate of C-reactive protein reaction in cerebrospinal fluid were 0%, 11.54 %, 75.00% and 100.00% in control group, aseptic meningitis group, tuberculous meningitis group and purulent meningitis group, respectively (p<0. 01). Considering above results, cerebrospinal fluid lactate level and C-reactive protein reaction could be good indices for differentiation and evaluation of the effect of treatment in various meningitis.

Keywords :CSF; Lactate; CRP; Meningitis